Fresco on a pillar in the Duomo.

Originally part of a polyptych executed for the church of San Niccolo in Cafaggio, Florence.
Other pieces exist around the world, including St Augustine in Rome.

One of the known eight panels from the external pillars of the Altar of the Eucharist in Siena Duomo. The panels represent the Four Doctors of the Church: S. Jerome, Gregory, Ambrose, Augustine as well as the four patron saints of Siena: S. Ansanus, Victor, Savinus and Crescentius.

Inscribed, lower right, on the cartellino on the pilaster: Franciscus benalius Filius petri / Albado (Francesco Benaglio, son of Pietro, dealer in cereals); lower center on the step below the saint: .SS. HIERONYMVS.

Nicolo Corso: born Pieve di Vico, Corsica 1446, died Liguria 1513

The high altar is flanked by two frescoes of the life of St Jerome.

Extracting the thorn represents either monastic celibacy, or Christian charity, or ...

The first known work by Domenico Ghirlandaio is the apse fresco in the parish church at Cercina. Saints Jerome, Barbara and Anthony Abbot are portrayed within a false architecture with niches divided by fluted pilaster strips and Corinthian capitals.

According to the Golden Legend, Saint Jerome retired to Bethlehem, where he encountered the lion. The location is suggested by the details of the palm trees, the Turks with their turbans and some exotic animals.

The setting is Oriental, although the buildings in the background recall the Scuola degli Schiavoni.