Originally located in the Duomo in Florence.
To the right of God the Father, the Virgin offers her breast as a means of intercession, while indicating a group of eight diminutive figures who gaze up at her Son.
Christ looks towards his Father, gesturing to his Mother with his left hand, while with his right hand he indicates the wound in his side, drawing a visual parallel between wound and breast as means of intercession.
Christ's insrcribed words read: 'My Father, let those be saved for whom you wished me to suffer the Passion.' The Virgin's read: 'Dearest son, because of the milk that I gave you, have mercy on them.'

In the upper level, with ancient gestures of intercession, the Madonna shows her breasts and Christ his wounds to the Eternal Father, enraged and bent on hurling pestilential arrows with the assistance of host of angels. Below two pairs of angels are trying to break the arrows. Both Christ and His Mother indicate the supplicant community below.
The arrival of the plague in San Gimignano in the spring of 1464 revived devotion to St Sebastian. The Augustinian community agreed with the Compagnia di San Sebastiano to commission a fresco of Saint Sebastian Intercessor in Sant'Agostino.
The saint, clothed instead of naked and pierced with arrows, stands surrounded by a diverse assembly of devotees sheltering them under his cloak in the manner of the 'Misericordia'.

Chapter 39 of the Speculum is devoted to the theme of intercession. Illustrated versions show the Virgin exposing her breast to Christ in one picture and Christ, his arms raised in a gesture of prayer, exhibiting his wounds to God (below).

Christ exhibits his wounds to God.